Role of SerpinA3 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts
Silencing SerpinA3 attenuated the expression of proinflammatory mediators, adipogenic differentiation, and hyaluronan production. Our results indicate that SerpinA3 plays a significant role in GO and may serve as a novel therapeutic target.
Authors
- Sun Young Jang (ORCID: https://orcid.org/0000-0002-0613-8356)
- JaeSang Ko (ORCID: https://orcid.org/0000-0002-3011-7213)
- Jin Sook Yoon (ORCID: https://orcid.org/0000-0002-8751-9467)
- Min‐Seok Kim (ORCID: https://orcid.org/0000-0003-3425-882X)
- Jae Woo Kim (ORCID: https://orcid.org/0000-0001-5456-9495)
- Soo Hyun Choi (ORCID: https://orcid.org/0000-0003-1421-5283)
- Hyun Young Park
Institutions
- Yonsei University (KR)
- Soonchunhyang University (KR)
- Severance Hospital (KR)
- Bucheon University (KR)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1167/iovs.66.4.20
- Citations
- 1
- Primary Topic
- Ophthalmology and Eye Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Korea Health Industry Development Institute