Iron-Sulfur Clusters and Iron Responsive Element Binding Proteins Mediate Iron Accumulation in Corneal Endothelial Cells in Fuchs Dystrophy
We identified differential gene expression of proteins responsible for ISC synthesis, ISC-containing proteins, IREBPs that mediate cellular iron homeostasis, and mitofusin, which promotes mitochondrial fusion in FECD. We also identified increased susceptibility to ferroptosis after ferredoxin 1 knockdown in CECs. These results advance an ISC- and IREBP-mediated mechanism of iron accumulation in FECD CECs.
Authors
- Pornpoj Phruttiwanichakun (ORCID: https://orcid.org/0000-0003-3045-3919)
- Aliasger K. Salem (ORCID: https://orcid.org/0000-0002-1923-6633)
- Matthew G. Field (ORCID: https://orcid.org/0000-0002-3459-376X)
- Hanna Shevalye
- Gregory A. Schmidt (ORCID: https://orcid.org/0000-0002-5013-6323)
- Jessica M. Skeie
- Mark A. Greiner (ORCID: https://orcid.org/0000-0002-7170-6655)
- Timothy Eggleston
- Emma M. Hartness
Institutions
- University of Iowa (US)
- Minnesota Eye Consultants (US)
- Minnesota Lions Eye Bank (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1167/iovs.66.4.23
- Citations
- 2
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- National Science Foundation
- National Eye Institute