Symptomatic Necrosis With Dual Immune-Checkpoint Inhibition and Radiosurgery for Brain Metastases

This cohort study evaluates whether immune-checkpoint inhibition therapy concurrent with radiosurgery is associated with risk of symptomatic radionecrosis among US patients with brain metastases.

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Publication Details

Journal
JAMA Network Open
Published
2025-04-09
DOI
https://doi.org/10.1001/jamanetworkopen.2025.4347
Citations
14
Primary Topic
Brain Metastases and Treatment
Type
article
Field-Weighted Citation Impact
21.26

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article

Symptomatic Necrosis With Dual Immune-Checkpoint Inhibition and Radiosurgery for Brain Metastases

Scott Floyd, Sebastian Winter, Chunhao Wang, R.F. Shenker et al.
14 citations
JAMA Network Open
Brain Metastases and Treatment
21.26
article

Symptomatic Necrosis With Dual Immune-Checkpoint Inhibition and Radiosurgery for Brain Metastases

Scott Floyd, Sebastian Winter, Chunhao Wang, R.F. Shenker, Karen Allen, Peter G. Hendrickson, Trey C. Mullikin, Zachary J. Reitman, Paul W. Sperduto, Helen Alice Shih, Jörg Dietrich, Zihan Wan, Warren Floyd, Jeffrey Clarke, Donna Niedzwiecki, Eugene Vaios, David Carpenter, John P. Kirkpatrick, April K.S. Salama
article en
14 citations

Abstract

This cohort study evaluates whether immune-checkpoint inhibition therapy concurrent with radiosurgery is associated with risk of symptomatic radionecrosis among US patients with brain metastases.

JAMA Network OpenVol. 8(4)
The University of Texas MD Anderson Cancer Center (US), Duke University (US), Massachusetts General Hospital (US), Duke Medical Center (US), Duke University Hospital (US)
Amgen, Bristol-Myers Squibb, Pfizer, Regeneron Pharmaceuticals, National Institutes of Health, National Cancer Institute, Janssen Pharmaceuticals, Duke Cancer Institute
Good health and well-being
Openalex Percentile: Top 0%
Brain Metastases and Treatment
21.26
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