Symptomatic Necrosis With Dual Immune-Checkpoint Inhibition and Radiosurgery for Brain Metastases
This cohort study evaluates whether immune-checkpoint inhibition therapy concurrent with radiosurgery is associated with risk of symptomatic radionecrosis among US patients with brain metastases.
Authors
- Scott Floyd (ORCID: https://orcid.org/0000-0002-8067-2426)
- Sebastian Winter (ORCID: https://orcid.org/0000-0001-8836-0235)
- Chunhao Wang (ORCID: https://orcid.org/0000-0002-6945-7119)
- R.F. Shenker (ORCID: https://orcid.org/0000-0001-6552-6255)
- Karen Allen
- Peter G. Hendrickson (ORCID: https://orcid.org/0000-0002-3068-9350)
- Trey C. Mullikin (ORCID: https://orcid.org/0000-0002-1099-1763)
- Zachary J. Reitman (ORCID: https://orcid.org/0000-0002-9122-9550)
- Paul W. Sperduto (ORCID: https://orcid.org/0000-0002-4628-7161)
- Helen Alice Shih (ORCID: https://orcid.org/0000-0003-1550-9726)
- Jörg Dietrich (ORCID: https://orcid.org/0000-0001-8291-0136)
- Zihan Wan (ORCID: https://orcid.org/0009-0005-9359-6417)
- Warren Floyd (ORCID: https://orcid.org/0000-0003-4371-8453)
- Jeffrey Clarke (ORCID: https://orcid.org/0000-0001-5647-0245)
- Donna Niedzwiecki (ORCID: https://orcid.org/0000-0002-3566-0450)
- Eugene Vaios (ORCID: https://orcid.org/0000-0003-2122-6650)
- David Carpenter (ORCID: https://orcid.org/0000-0002-9261-7168)
- John P. Kirkpatrick (ORCID: https://orcid.org/0000-0002-4019-0350)
- April K.S. Salama (ORCID: https://orcid.org/0000-0002-8105-5374)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Duke University (US)
- Massachusetts General Hospital (US)
- Duke Medical Center (US)
- Duke University Hospital (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.4347
- Citations
- 14
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 21.26
Funders
- Amgen
- Bristol-Myers Squibb
- Pfizer
- Regeneron Pharmaceuticals
- National Institutes of Health
- National Cancer Institute
- Janssen Pharmaceuticals
- Duke Cancer Institute