Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1
Altogether, our results establish a role of the IRE1/P4HB axis in the regulation of collagen production and support its implication in the pathogenesis of liver fibrosis.
Authors
- Jessica L. Maiers (ORCID: https://orcid.org/0000-0001-7798-2274)
- Hery Urra (ORCID: https://orcid.org/0000-0002-6846-558X)
- Béatrice Bailly‐Maitre (ORCID: https://orcid.org/0000-0002-8389-8498)
- Fanny Aprahamian (ORCID: https://orcid.org/0000-0002-2457-8435)
- Eija Jokitalo (ORCID: https://orcid.org/0000-0002-4159-6934)
- Claudio Hetz (ORCID: https://orcid.org/0000-0003-1120-7966)
- Mateus Milani (ORCID: https://orcid.org/0000-0001-5004-3250)
- Menghao Huang (ORCID: https://orcid.org/0000-0002-2389-8680)
- Lars Plate (ORCID: https://orcid.org/0000-0003-4363-6116)
- Reese Baxter (ORCID: https://orcid.org/0009-0002-5231-416X)
- Younis Hazari (ORCID: https://orcid.org/0000-0003-1004-3218)
- Jan Georg Hengstler (ORCID: https://orcid.org/0000-0002-1427-5246)
- Helena Vihinen (ORCID: https://orcid.org/0000-0003-3862-9237)
- Fabienne Foufelle (ORCID: https://orcid.org/0000-0002-0752-622X)
- X. Charlie Dong (ORCID: https://orcid.org/0000-0001-5452-6882)
- Giovanni Tamburini
- Vlad Ratziu (ORCID: https://orcid.org/0000-0002-6865-3791)
- Jorge F. Silva (ORCID: https://orcid.org/0000-0002-0256-282X)
- Guido Kroemer (ORCID: https://orcid.org/0000-0002-9334-4405)
- Valeria A. Garcia Lopez
- Sylvère Durand (ORCID: https://orcid.org/0000-0001-6356-1006)
- Lama Habbouche
- Luis González-Rojas (ORCID: https://orcid.org/0000-0002-2364-0508)
- Javier Diaz
- Ignacio Tapia-Dufey
Institutions
- University of Helsinki (FI)
- Buck Institute for Research on Aging (US)
- Inserm (FR)
- Institut Universitaire de France (FR)
- TU Dortmund University (DE)
- Vanderbilt University (US)
- Université Côte d'Azur (FR)
- Université Paris Cité (FR)
- Institut Gustave Roussy (FR)
- San Sebastián University (CL)
- Sorbonne Université (FR)
- Centre de Recherche des Cordeliers (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine (FR)
- Hôpital Européen (FR)
- Centre Méditerranéen de Médecine Moléculaire (FR)
- Pitié-Salpêtrière Hospital (FR)
- Center for Climate and Resilience Research (CL)
- Fondation pour l’innovation en Cadiométabolisme et Nutrition (FR)
- Leibniz Research Centre for Working Environment and Human Factors (DE)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of Chile (CL)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Hepatology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1097/hep.0000000000001335
- Citations
- 2
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 2.30