Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1

Altogether, our results establish a role of the IRE1/P4HB axis in the regulation of collagen production and support its implication in the pathogenesis of liver fibrosis.

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Publication Details

Journal
Hepatology
Published
2025-04-08
DOI
https://doi.org/10.1097/hep.0000000000001335
Citations
2
Primary Topic
Endoplasmic Reticulum Stress and Disease
Type
article
Field-Weighted Citation Impact
2.30
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article

Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1

Jessica L. Maiers, Hery Urra, Béatrice Bailly‐Maitre, Fanny Aprahamian et al.
2 citations
Hepatology
Endoplasmic Reticulum Stress and Disease
2.30
article

Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1

Jessica L. Maiers, Hery Urra, Béatrice Bailly‐Maitre, Fanny Aprahamian, Eija Jokitalo, Claudio Hetz, Mateus Milani, Menghao Huang, Lars Plate, Reese Baxter, Younis Hazari, Jan Georg Hengstler, Helena Vihinen, Fabienne Foufelle, X. Charlie Dong, Giovanni Tamburini, Vlad Ratziu, Jorge F. Silva, Guido Kroemer, Valeria A. Garcia Lopez, Sylvère Durand, Lama Habbouche, Luis González-Rojas, Javier Diaz, Ignacio Tapia-Dufey
article en
2 citations

Abstract

Altogether, our results establish a role of the IRE1/P4HB axis in the regulation of collagen production and support its implication in the pathogenesis of liver fibrosis.

HepatologyVol. 83(1)
University of Helsinki (FI), Buck Institute for Research on Aging (US), Inserm (FR), Institut Universitaire de France (FR), TU Dortmund University (DE), Vanderbilt University (US), Université Côte d'Azur (FR), Université Paris Cité (FR), Institut Gustave Roussy (FR), San Sebastián University (CL), Sorbonne Université (FR), Centre de Recherche des Cordeliers (FR), Assistance Publique – Hôpitaux de Paris (FR), Hôpital Européen Georges-Pompidou (FR), Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine (FR), Hôpital Européen (FR), Centre Méditerranéen de Médecine Moléculaire (FR), Pitié-Salpêtrière Hospital (FR), Center for Climate and Resilience Research (CL), Fondation pour l’innovation en Cadiométabolisme et Nutrition (FR), Leibniz Research Centre for Working Environment and Human Factors (DE), Indiana University School of Medicine, Indiana University – Purdue University Indianapolis (US), University of Chile (CL), Vanderbilt University Medical Center (US)
Good health and well-being
Openalex Percentile: Top 14%
Endoplasmic Reticulum Stress and Disease
2.30
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