Deciphering genetic regulation at single-cell resolution in gastric cancer
Understanding cell-type-specific genetic regulation in gastric cancer is essential for uncovering disease susceptibility. By performing single-cell eQTL mapping in gastric tissues, Bian et al.<sup>1</sup> identified previously uncharacterized regulatory genetic mechanisms, risk genes, and co-localization signals associated with gastric cancer susceptibility, providing insights into its pathogenesis and potential therapeutic approaches.
Authors
- Leng Han (ORCID: https://orcid.org/0000-0002-7380-2640)
- Chengxuan Chen (ORCID: https://orcid.org/0000-0002-9650-1437)
Institutions
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Cell Genomics
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.xgen.2025.100846
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Foundation for the National Institutes of Health
- National Institutes of Health