Tenecteplase compared to alteplase before mechanical thrombectomy enhances 1-h recanalization and reduces disability in large-vessel occlusion
Real-world observations reveal tenecteplase has increased ER rates compared to alteplase within 1 h of IVT and reduced disability in LVO patients. Further randomized trials are warranted to evaluate the effect of tenecteplase rapid bridging mechanical thrombectomy.
Authors
- Fangfang Zhang
- Xunming Ji (ORCID: https://orcid.org/0000-0003-0293-2744)
- Fengyuan Che
- Weidong Liu (ORCID: https://orcid.org/0000-0002-9791-4663)
- Lulan Li (ORCID: https://orcid.org/0000-0003-4506-721X)
- Hongxing Han
- Xueqiao Jiao (ORCID: https://orcid.org/0000-0002-7193-8077)
- Fuxia Yang
- Xiao Wu (ORCID: https://orcid.org/0000-0003-4866-3033)
- Liyong Zhang
- Lu Wang (ORCID: https://orcid.org/0000-0002-8643-6790)
- Xiuhai Guo (ORCID: https://orcid.org/0000-0001-6576-0033)
- Peifu Wang (ORCID: https://orcid.org/0000-0003-4993-1386)
- Jialu Li (ORCID: https://orcid.org/0000-0002-0513-7597)
Institutions
- Capital Medical University (CN)
- Xuan Wu Hospital of the Capital Medical University (CN)
- Linyi People's Hospital (CN)
- Aerospace Center Hospital (CN)
- Liaocheng People's Hospital (CN)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1007/s00415-025-13084-2
- Citations
- 3
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- National Natural Science Foundation of China
- National Science and Technology Major Project