Exploring METRNL as a novel biomarker in sepsis: diagnostic potential and secretion mechanism
This pilot study demonstrates that METRNL is a novel potential biomarker for sepsis with diagnostic capability comparable to that of PCT. Serum METRNL rapidly increased during the early phase of sepsis. Mechanistically, it mainly originates from the endothelium during sepsis, and TLR4-ERK signaling mediates the rapid secretion of METRNL via the classical ER-Golgi pathway in response to LPS stimulation.
Authors
- Zhu‐Wei Miao
- Chao‐Yu Miao (ORCID: https://orcid.org/0000-0002-8176-3434)
- Yusheng Wang (ORCID: https://orcid.org/0000-0001-9761-5519)
- Jingxin Zhao (ORCID: https://orcid.org/0000-0001-8152-1374)
- Zhiyong Li (ORCID: https://orcid.org/0000-0001-6138-4712)
- Tian‐Ying Xu
- Mingyao Chen (ORCID: https://orcid.org/0000-0002-4795-9548)
- Yong-Qing Chang
Institutions
- Second Military Medical University (CN)
Publication Details
- Journal
- Journal of Intensive Care
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1186/s40560-025-00780-4
- Citations
- 2
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Natural Science Foundation of China