Association of bile acid diarrhea with symptoms and disease activity in Crohn’s disease: post-hoc clinical trial analysis of serum 7a-hydroxy-4cholestern-3-one, C4, in patients with active Crohn’s disease
In active CD, BAD was prevalent, particularly in isolated ileal disease, and associated with persistent diarrhea, but not endoscopic remission after treatment. These findings shed light on the discordance between symptomatic and endoscopic assessments observed in CD clinical trials and the challenges in treating isolated ileal disease. ClinicalTrials.gov NCT02065570.
Authors
- Ezequiel Neimark
- Brian G. Feagan (ORCID: https://orcid.org/0000-0002-6914-3822)
- David T. Rubin (ORCID: https://orcid.org/0000-0001-5647-1723)
- Robert Battat (ORCID: https://orcid.org/0000-0002-7421-9764)
- Soumya Kandi (ORCID: https://orcid.org/0000-0002-8007-3802)
- Ana P. Lacerda (ORCID: https://orcid.org/0009-0009-6291-9171)
- Peter M. Levine (ORCID: https://orcid.org/0000-0002-3246-9028)
- Xin Chen (ORCID: https://orcid.org/0000-0003-2619-0124)
- Qin Ji (ORCID: https://orcid.org/0000-0001-7325-1052)
- Sarah Blink Polakow
Institutions
- Western University (CA)
- Montreal General Hospital (CA)
- AbbVie (United States) (US)
- University of Chicago (US)
- Sanofi (United States) (US)
- Inflammation Research Foundation (US)
- Université de Montréal (CA)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1093/ecco-jcc/jjaf053
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00