Aberrant glucose metabolism drives dysfunction of CD4+ T cells in systemic lupus erythematosus and disease flares
CD4<sup>+</sup> T cells from SLE patients showed higher glucose metabolic activity than those from HCs, and the enhanced glucose metabolism of SLE-CD4<sup>+</sup> T cells was strongly correlated with disease activity, suggesting that glucose metabolic reprogramming plays an essential role in the pathogenesis of SLE.
Authors
- Jin Lu (ORCID: https://orcid.org/0000-0002-0946-3357)
- Hongtao Jin (ORCID: https://orcid.org/0000-0002-0638-707X)
- Aijing Liu (ORCID: https://orcid.org/0000-0002-5762-5592)
- Jun Ma (ORCID: https://orcid.org/0000-0003-2843-0769)
- Shaoxin Cui
- Meng Ding
- Jingjing He (ORCID: https://orcid.org/0000-0001-5574-1517)
- Fei Chang
- Qun Wang (ORCID: https://orcid.org/0000-0001-7929-7692)
- Xue Liu (ORCID: https://orcid.org/0000-0002-2104-9335)
- Xiaoping Wang (ORCID: https://orcid.org/0000-0001-6265-530X)
- Lin Yang (ORCID: https://orcid.org/0000-0001-5383-4779)
- Jinwen Zhao
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Central European Journal of Immunology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.5114/ceji.2025.149252
- Citations
- 1
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 1.67
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hebei Province
- Hebei Medical University