Short‐Term Effects of Folate Supplementation in Combination With Vitamin B6 for Treating Acute Manic Episodes in Bipolar I Disorder: A Randomized Controlled Trial
Our findings support the short-term use of folate as a beneficial adjunct in treating acute manic episodes in bipolar I disorder. However, the addition of vitamin B6 did not yield additional advantages. These results may inform future treatment guidelines targeting acute mania in bipolar disorder, advocating for folate supplementation as a potential strategy to enhance therapeutic outcomes.
Authors
- Mohsen Nematy (ORCID: https://orcid.org/0000-0003-3202-2709)
- Ali Talaeı (ORCID: https://orcid.org/0000-0002-7194-1479)
- Farzad Akbarzadeh (ORCID: https://orcid.org/0000-0002-5976-123X)
- Andisheh Talaei (ORCID: https://orcid.org/0000-0002-2619-2157)
- Dina Ganji
- Alireza Ebrahimi (ORCID: https://orcid.org/0000-0002-5904-5743)
Institutions
- Mashhad University of Medical Sciences (IR)
- University of Tehran (IR)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/brb3.70432
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Mashhad University of Medical Sciences