Mechanism by which hyperglycemia regulates precursor of brain<b>-</b>derived neurotrophic factor expression to exacerbate neurological injury and inflammation in a mouse model of spinal cord ischemia<b>-</b>reperfusion injury.
Hyperglycemia exacerbates neural injury and inflammatory response in SCIRI through upregulation of proBDNF expression, delaying motor functional recovery. Antagonizing proBDNF expression can alleviate neurological damage and promote functional recovery in diabetic mice after SCIRI.
Authors
- Xiaoping Miao (ORCID: https://orcid.org/0000-0002-6818-9722)
- Ru‐Ping Dai (ORCID: https://orcid.org/0000-0002-1027-6698)
- Tao Liu (ORCID: https://orcid.org/0000-0003-1016-4191)
- Hui Li (ORCID: https://orcid.org/0000-0001-6092-5222)
- Wei Luo (ORCID: https://orcid.org/0000-0003-1818-3469)
- Yiyu Xiong
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-12-28
- DOI
- https://doi.org/10.11817/j.issn.1672-7347.2024.240198
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00