Repeated Exposure to Sevoflurane in Neonatal Mice Induces Cognitive and Synaptic Impairments in a <scp>TTLL6</scp> ‐Mediated Tubulin Polyglutamylation Manner
Repeated neonatal sevoflurane exposure results in synaptic impairment through TTLL6-mediated tubulin polyglutamylation and increased Spastin expression, causing pre-adolescent cognitive dysfunction in mice. This process is initiated by Tau phosphorylation and missorting from axons to somatodendritic compartments.
Authors
- Yang Yu (ORCID: https://orcid.org/0000-0002-8303-8690)
- Jiafeng Yu
- Junyan Yao (ORCID: https://orcid.org/0000-0002-9553-7868)
- Jingyu Feng (ORCID: https://orcid.org/0000-0003-3181-4544)
- Yonghao Yu (ORCID: https://orcid.org/0000-0002-7289-7748)
- Yongyan Yang (ORCID: https://orcid.org/0000-0002-2189-2242)
- Yue Zhao (ORCID: https://orcid.org/0000-0001-5694-7904)
- Naqi Lian
Institutions
- Tianjin Medical University General Hospital (CN)
- Shanghai East Hospital (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/cns.70376
- Citations
- 2
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 2.64
Funders
- National Natural Science Foundation of China