Optimized Mouse Model of Sepsis‐Associated Encephalopathy: A Rational Standard Based on Modified <scp>SHIRPA</scp> Score and Neurobehaviors in Mice
This study establishes a reliable evaluation method for SAE in murine models, facilitating improved differentiation between SAE and non-SAE. Such advancements will enhance our understanding of the pathogenesis of SAE and guide more effective treatment strategies.
Authors
- Shuixiang Deng (ORCID: https://orcid.org/0000-0001-5460-7279)
- Ye Gong (ORCID: https://orcid.org/0000-0002-0874-9601)
- Yanqin Gao (ORCID: https://orcid.org/0000-0002-4915-9819)
- Mi Tian (ORCID: https://orcid.org/0000-0002-6446-1995)
- Xu Pei (ORCID: https://orcid.org/0000-0002-3011-9331)
- Feng Zhao (ORCID: https://orcid.org/0000-0002-8309-0536)
- Yuewen Xin
- Thomas Behnisch (ORCID: https://orcid.org/0000-0002-7842-3252)
- Yao Wang (ORCID: https://orcid.org/0000-0002-8801-8496)
Institutions
- Fudan University (CN)
- Huashan Hospital (CN)
- State Key Laboratory of Medical Neurobiology
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/cns.70365
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- National Natural Science Foundation of China
- Shanghai Hospital Development Center