<scp>TRPC4</scp> Mediates Trigeminal Neuropathic Pain via Ca <sup>2+</sup> ‐ <scp>ERK</scp> / <scp>P38</scp> ‐ <scp>ATF2</scp> Pathway in the Trigeminal Ganglion of Mice
This study provides the first evidence that TRPC4 plays a critical role in CION-induced trigeminal neuropathic pain by promoting the activation of the downstream transcription factor ATF2 via the Ca²<sup>2+</sup>-ERK/P38 pathway.
Authors
- Xiangnan Zhang (ORCID: https://orcid.org/0000-0002-7603-7403)
- Xinlong Ke
- Feng Luo (ORCID: https://orcid.org/0000-0001-6645-9496)
- Gang Chen (ORCID: https://orcid.org/0000-0003-4262-9491)
- Youfa Zhou
- Yeru Chen
- Yongjie Wang (ORCID: https://orcid.org/0000-0002-0306-3088)
- Huajing Cai
- Xing Zheng
- Qian Hu (ORCID: https://orcid.org/0000-0002-1735-5903)
Institutions
- Hangzhou Normal University (CN)
- Sir Run Run Shaw Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/cns.70368
- Citations
- 2
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Zhejiang University
- Natural Science Foundation of Zhejiang Province