Computational Modeling of Effects of <i>PKP2</i> Gene Therapy on Ventricular Conduction Properties in Arrhythmogenic Cardiomyopathy
The extent of successful ventricular myocyte transduction anticipated to be achieved in <i>PKP2</i> adeno-associated viral gene therapy trials will likely not restore conduction velocity to levels sufficient to decrease the risk of reentrant arrhythmias. Transduction efficiency of 60% to 80% would be required to restore conduction velocity to 50% of normal.
Authors
- Yoram Rudy (ORCID: https://orcid.org/0000-0001-7561-4371)
- Jeffrey E. Saffitz (ORCID: https://orcid.org/0000-0001-8568-9457)
- André G. Kléber (ORCID: https://orcid.org/0000-0002-3233-2005)
- Jan Kučera (ORCID: https://orcid.org/0000-0003-0310-6962)
- Alessio Ostini
Institutions
- University of Bern (CH)
- Bern University of Applied Sciences (CH)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Washington University in St. Louis (US)
Publication Details
- Journal
- Circulation Arrhythmia and Electrophysiology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1161/circep.124.013658
- Citations
- 2
- Primary Topic
- Cardiovascular Effects of Exercise
- Type
- article
- Field-Weighted Citation Impact
- 2.78