Breaking the Cycle of Echinococcosis: A Mathematical Modeling Approach

This study presents a mathematical model of the transmission and spread of the <i>Echinococcus granulosus</i> parasite. The model incorporates host mobility, laws governing the dynamics of Echinococcosis transmission between hosts, and control and prevention measures. The basic reproductive number of the proposed model is calculated, and a sensitivity analysis is performed to identify the parameters that most influence the dynamics of transmission and spread of the disease among its hosts. The study evaluates two control strategies-dog deworming and sheep vaccination-based on their respective target reproductive numbers. The impact of these control and prevention measures is investigated through numerical simulations, which reveal that the dog deworming strategy consistently reduces infections in humans. In contrast, the sheep vaccination strategy demonstrates a more favorable scenario for disease eradication in both hosts. In addition, simulations show a close relationship between the early detection of the disease and the recovery of the patient.

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Publication Details

Journal
Tropical Medicine and Infectious Disease
Published
2025-04-09
DOI
https://doi.org/10.3390/tropicalmed10040101
Citations
1
Primary Topic
Parasitic infections in humans and animals
Type
article
Field-Weighted Citation Impact
1.47
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article

Breaking the Cycle of Echinococcosis: A Mathematical Modeling Approach

Juan Pablo Gutiérrez-Jara, Leidy Yissedt Lara-Díaz, Beatriz Cancino‐Faure, Ignacio Barradas et al.
1 citations
Tropical Medicine and Infectious Disease
Parasitic infections in humans and animals
1.47
article

Breaking the Cycle of Echinococcosis: A Mathematical Modeling Approach

Juan Pablo Gutiérrez-Jara, Leidy Yissedt Lara-Díaz, Beatriz Cancino‐Faure, Ignacio Barradas, Richard Lagos, Andrei González-Galeano
article en
1 citations

Abstract

This study presents a mathematical model of the transmission and spread of the <i>Echinococcus granulosus</i> parasite. The model incorporates host mobility, laws governing the dynamics of Echinococcosis transmission between hosts, and control and prevention measures. The basic reproductive number of the proposed model is calculated, and a sensitivity analysis is performed to identify the parameters that most influence the dynamics of transmission and spread of the disease among its hosts. The study evaluates two control strategies-dog deworming and sheep vaccination-based on their respective target reproductive numbers. The impact of these control and prevention measures is investigated through numerical simulations, which reveal that the dog deworming strategy consistently reduces infections in humans. In contrast, the sheep vaccination strategy demonstrates a more favorable scenario for disease eradication in both hosts. In addition, simulations show a close relationship between the early detection of the disease and the recovery of the patient.

Tropical Medicine and Infectious DiseaseVol. 10(4)
Mathematics Research Center (MX), Universidad El Bosque (CO), Catholic University of the Maule (CL), Universidad de Magallanes (CL)
Good health and well-being
Openalex Percentile: Top 21%
Parasitic infections in humans and animals
1.47
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