Synthesis of 12- to 26-Membered Macrocyclic Dienes by Directed Intramolecular Alkene/Alkyne Cross-Coupling
The first iridium-catalyzed intramolecular alkene/alkyne cross-coupling reaction has been developed to prepare a wide range of 12- to 26-membered macrocyclic 1,3-dienes. This operationally simple protocol proceeded by NHTs amide-enabled alkenyl C-H functionalization and exhibited wide functionality tolerance and excellent <i>E/Z</i> ratio selectivity.
Authors
- Xiuying Liu (ORCID: https://orcid.org/0000-0001-6414-6349)
- Xiandie Zhang
- Guofu Zhong (ORCID: https://orcid.org/0000-0001-9497-9069)
- Rui He (ORCID: https://orcid.org/0000-0002-8314-9155)
- Xiaoli Li (ORCID: https://orcid.org/0000-0001-9689-9054)
- Jian Zhang (ORCID: https://orcid.org/0000-0001-8734-3003)
- Yini Wang (ORCID: https://orcid.org/0000-0002-1154-6733)
Institutions
- Eastern Institute of Technology (NZ)
- Hangzhou Normal University (CN)
- Affiliated Hospital of Hangzhou Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1021/acs.orglett.5c01106
- Citations
- 3
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province