Left Atrial Myocardial Mechanics: Association With Cognitive Dysfunction, Cerebrovascular Disease, and Circulating Biomarkers
Reduced LA strain was associated with cognitive impairment, primarily of vascular origin, and a higher burden of cerebral small vessel disease. LAScd may be a biomarker of VCI in at-risk subjects without atrial fibrillation.
Authors
- Caroline Robert (ORCID: https://orcid.org/0000-0002-0381-593X)
- Narayanaswamy Venketasubramanian (ORCID: https://orcid.org/0000-0003-3593-6362)
- Siew Pang Chan (ORCID: https://orcid.org/0000-0001-6239-6483)
- Josephine Lunaria Berboso
- Christopher Chen (ORCID: https://orcid.org/0000-0002-1047-9225)
- Mark Richards (ORCID: https://orcid.org/0000-0002-2023-8177)
- Eugene S.J. Tan (ORCID: https://orcid.org/0000-0001-7273-6883)
- Joyce Ruifen Chong (ORCID: https://orcid.org/0000-0002-2869-0096)
- Saima Hilal (ORCID: https://orcid.org/0000-0001-5434-5635)
- Lieng Hsi Ling (ORCID: https://orcid.org/0000-0001-6063-8530)
- Ming Ann Sim (ORCID: https://orcid.org/0000-0002-5699-3553)
- Lingli Gong
- Mitchell K.P. Lai (ORCID: https://orcid.org/0000-0001-7685-1424)
- Boon Yeow Tan
- Hazliza Hazli (ORCID: https://orcid.org/0009-0007-4824-0432)
Institutions
- National University of Singapore (SG)
- Raffles Institution (SG)
- University Health System (US)
- Cardiovascular Institute Hospital (JP)
- National University Heart Centre Singapore (SG)
- National University Health System (SG)
- University of Otago (NZ)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1161/jaha.123.036931
- Citations
- 5
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 6.94