Spontaneous Coronary Artery Dissection and a Family History of Aortic Dissection: A Genetic Association Study
Our study supports a complex genetic landscape underlying SCAD, implicating rare monogenic pathogenic variants and polygenic risk. We identified pathogenic variants in patients with SCAD with a family history of AD, highlighting potential genetic links between these vascular disorders. The findings underscore the importance of genetic screening in patients with SCAD with a history of AD to identify individuals at risk and guide preventive strategies.
Authors
- Monique Bax (ORCID: https://orcid.org/0000-0003-2468-0250)
- Eleni Giannoulatou (ORCID: https://orcid.org/0000-0002-7084-6736)
- Nicholas Collins (ORCID: https://orcid.org/0000-0003-4722-0214)
- Robert M. Graham (ORCID: https://orcid.org/0000-0002-1042-2587)
- Stephanie Hesselson (ORCID: https://orcid.org/0000-0002-4521-5086)
- Siiri E. Iismaa (ORCID: https://orcid.org/0000-0003-2409-7356)
- Ingrid Tarr (ORCID: https://orcid.org/0000-0002-4847-2838)
- Keerat Junday (ORCID: https://orcid.org/0000-0001-7122-3226)
- Lucy McGrath‐Cadell (ORCID: https://orcid.org/0000-0001-6627-3739)
- Emma M. Rath (ORCID: https://orcid.org/0000-0002-8430-5236)
- David W.M. Muller (ORCID: https://orcid.org/0000-0002-5281-0166)
- Michael Troup (ORCID: https://orcid.org/0000-0003-3017-7029)
- Jason C. Kovacic (ORCID: https://orcid.org/0000-0003-4555-769X)
- Yunkai Gao
Institutions
- St. Vincent's Birmingham (US)
- Victor Chang Cardiac Research Institute (AU)
- John Hunter Hospital (AU)
- UNSW Sydney (AU)
- St Vincent's Hospital Melbourne (AU)
- Saint Vincent's Catholic Medical Center (US)
- The Catholic University of Korea St. Vincent's Hospital (KR)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1161/jaha.124.037921
- Citations
- 1
- Primary Topic
- Cardiovascular Issues in Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 1.39