Cross-sectional and longitudinal association of seven DNAm-based predictors with metabolic syndrome and type 2 diabetes
GrimAA, PhenoAA difference and mortality risk score, derived from the "second-generation" clocks, demonstrated significant associations with both MetS and T2D. These DNAm-based predictors may be useful biomarkers for risk stratification and disease prognosis in our study sample of European ancestry. Further research is warranted to investigate the generalizability of our findings across different ancestries and to examine the underlying shared biological mechanisms.
Authors
- Wolfgang Rathmann (ORCID: https://orcid.org/0000-0001-7804-1740)
- Karsten Suhre (ORCID: https://orcid.org/0000-0001-9638-3912)
- Suet Mei Chew (ORCID: https://orcid.org/0000-0002-6374-052X)
- Christian Herder (ORCID: https://orcid.org/0000-0002-2050-093X)
- Alexander Teumer (ORCID: https://orcid.org/0000-0002-8309-094X)
- Pamela R. Matías‐García (ORCID: https://orcid.org/0000-0002-3906-5405)
- Mélanie Waldenberger (ORCID: https://orcid.org/0000-0003-0583-5093)
- Christian Gieger (ORCID: https://orcid.org/0000-0001-6986-9554)
- Annette Peters (ORCID: https://orcid.org/0000-0001-6645-0985)
- Juliane Winckelmann
Institutions
- Zimmer Biomet (Netherlands) (NL)
- Munich University of Applied Sciences (DE)
- Cornell University (US)
- Universitätsmedizin Greifswald (DE)
- Helmholtz Zentrum München (DE)
- Düsseldorf University Hospital (DE)
- German Centre for Cardiovascular Research (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- Weill Cornell Medical College in Qatar (QA)
- German Center for Diabetes Research (DE)
- Weill Cornell Medicine (US)
- Heinrich Heine University Düsseldorf (DE)
- Technical University of Munich (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1186/s13148-025-01862-8
- Citations
- 3
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Bundesministerium für Gesundheit
- Helmholtz Zentrum München