Mendelian Randomization Combined with Single-Cell Transcriptome Analysis Reveals the Role of the Key Gene PCLAF in the Pathogenesis of Atopic Dermatitis
Our study highlights the importance of PCLAF in the pathogenesis of AD, indicating it as a potential target for future therapeutic strategies aimed at alleviating the disease by addressing genetic and metabolic disruptions.
Authors
- Xuejie Chen
- Rui Tao (ORCID: https://orcid.org/0000-0001-8782-4421)
- Zhanyong Zhu (ORCID: https://orcid.org/0000-0003-4323-4862)
- Qi Zhang (ORCID: https://orcid.org/0000-0003-0564-9215)
- Yingying Wang (ORCID: https://orcid.org/0000-0003-0745-8850)
- Sicheng Li (ORCID: https://orcid.org/0000-0003-1174-3670)
- Lingling Yan (ORCID: https://orcid.org/0000-0001-5659-7414)
- Shengzhi Zhou
- Sis Aghayants
Institutions
- Wuhan University (CN)
- Hubei Provincial Hospital of Traditional Chinese Medicine (CN)
- Renmin Hospital of Wuhan University (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Clinical Cosmetic and Investigational Dermatology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/ccid.s506139
- Citations
- 3
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 6.01