Potential inappropriate medications and drug–drug interactions in adverse drug reactions in the elderly: a retrospective study in a pharmacovigilance database

The incidence of PIMs and pDDIs was found to be relatively high in the elderly, especially in the treatment of cardiovascular and cerebrovascular diseases and non-steroidal anti-inflammatory drugs (NSAIDs), and relevant factors have been identified. Healthcare institutions should reinforce the management of rational drug use in the elderly to mitigate the occurrence of PIMs and pDDIs, thereby enhancing medication safety.