Stimulation of regulatory dendritic cells suppresses cytotoxic T cell function and alleviates DEN-induced liver injury, fibrosis and hepatocellular carcinoma
Overall, these data suggest that stimulation of regulatory dendritic cells (rDCs) in the liver by LAP suppresses cytotoxic T-cell function and alleviates DEN-induced liver damage, fibrosis and tumorigenesis.
Authors
- Ping Gong (ORCID: https://orcid.org/0000-0002-8766-260X)
- Qiaoming Long (ORCID: https://orcid.org/0000-0001-8243-589X)
- Menglei Wang (ORCID: https://orcid.org/0000-0003-3305-4817)
- Jun‐Jie Wang (ORCID: https://orcid.org/0000-0002-4800-6351)
- Han Wang (ORCID: https://orcid.org/0000-0002-1123-4086)
- Shusen Zheng (ORCID: https://orcid.org/0000-0003-1459-8261)
- Mengyu Li (ORCID: https://orcid.org/0000-0001-9145-8903)
- Qingqing Liu (ORCID: https://orcid.org/0000-0002-3051-8295)
- Di Wu (ORCID: https://orcid.org/0000-0001-8331-2357)
Institutions
- Soochow University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1565486
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China