T-cell receptor dynamics in digestive system cancers: a multi-layer machine learning approach for tumor diagnosis and staging
Our investigation provides novel insights into TCR repertoire variations in digestive system tumors, and highlight the potential of immune repertoire features as powerful diagnostic tools for understanding cancer progression and potentially improving clinical decision-making.
Authors
- Xiangze Li (ORCID: https://orcid.org/0009-0007-8123-8836)
- Bin Wang (ORCID: https://orcid.org/0000-0002-0563-5668)
- Changjin Yuan
- Fang Wang (ORCID: https://orcid.org/0000-0002-8259-8557)
- Hong Wang (ORCID: https://orcid.org/0000-0003-0212-5379)
- Yanan Zhen
Institutions
- Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Jinan University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1556165
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.81