FGFR3-TACC3 fusion gene promotes glioblastoma malignant progression through the activation of STAT3 signaling pathway
F3-T3 facilitates the proliferation, invasion, migration and EMT of glioma cells, thereby promoting their malignant progression through STAT3 signaling activation. These findings highlight its potential as a therapeutic target for glioma treatment.
Authors
- Jianshen Liang (ORCID: https://orcid.org/0009-0006-1539-8113)
- Xiude Ren
- Xisen Wang (ORCID: https://orcid.org/0000-0002-6091-9217)
- Jiahe Guo (ORCID: https://orcid.org/0009-0008-8828-8155)
- Xuya Wang (ORCID: https://orcid.org/0000-0001-5538-5217)
- Yiming Li (ORCID: https://orcid.org/0000-0003-0236-9840)
- Xuejun Yang (ORCID: https://orcid.org/0000-0001-7056-1223)
- Tao Li (ORCID: https://orcid.org/0000-0002-5232-5558)
- Shengping Yu
Institutions
- Tianjin Medical University General Hospital (CN)
- Beijing Tsinghua Chang Gung Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.3389/fonc.2025.1560008
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63