Macrophage caspase-8 inhibition accelerates necrotic core expansion in atheroma plaque in mice
The study highlights the role of caspase-8 in atherosclerosis in tuning the balance between apoptosis and necroptosis. Caspase-8 inhibition leads to a switch towards necroptosis and accumulation of dead cell corpses that contributes to enhanced plaque severity. These findings suggest that reducing caspase-8-regulated necroptosis and necrosis in macrophages could represent a therapeutic strategy to stabilize plaques and reduce cardiovascular risk.
Authors
- C. Thomas (ORCID: https://orcid.org/0000-0003-1956-6154)
- Stéphanie Solier (ORCID: https://orcid.org/0000-0003-3867-4644)
- Éric Solary (ORCID: https://orcid.org/0000-0002-8629-1341)
- Charlène Magnani (ORCID: https://orcid.org/0000-0002-6888-7045)
- Thomas Pilot
- Peter Vandenabeele (ORCID: https://orcid.org/0000-0001-5285-9835)
- Tom Vanden Berghe (ORCID: https://orcid.org/0000-0002-1633-0974)
- David Masson (ORCID: https://orcid.org/0000-0003-1692-0699)
- Antoine Jalil
Institutions
- HOGENT University of Applied Sciences and Arts (BE)
- University of Antwerp (BE)
- Inserm (FR)
- Université de Bourgogne (FR)
- Université Paris-Saclay (FR)
- Ghent University Hospital (BE)
- Institut Gustave Roussy (FR)
- Vlaams Instituut voor Biotechnologie (BE)
- Ghent University (BE)
- CHU Dijon Bourgogne (FR)
- Centre de recherche Translationnelle en Médecine moléculaire (FR)
- VIB-UGent Center for Inflammation Research (BE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1513637
- Citations
- 4
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 5.42