Ocular Safety and Visual Acuity Stability in Pediatric Patients With Optic Pathway Gliomas and Orbital Plexiform Neurofibromas Treated With BRAF and MEK Inhibitors

BRAF and MEK inhibitors demonstrate ocular safety in children, including those with OPG/OPN, with rare, reversible OAE and stable VA. These findings support their use in pediatric patients even with optic pathway involvement. Regular ophthalmologic monitoring with OCT and VA assessments remains essential for safe, long-term use.