Chimeric autoantibody receptor T cells specifically eliminate Graves’ Disease autoreactive B cells
Thus, TSHR CAAR T cells show promise in eliminating the disease-causing autoreactive B cells in GD without eliminating healthy cells. This treatment mechanism also has the potential to be used in other B cell-mediated autoimmune diseases.
Authors
- Abigail Cheever (ORCID: https://orcid.org/0000-0003-3541-1507)
- K. Scott Weber (ORCID: https://orcid.org/0000-0003-3688-2191)
- Mackenzie Hansen (ORCID: https://orcid.org/0009-0004-9990-7194)
- Kim L. O’Neill (ORCID: https://orcid.org/0000-0002-8747-6217)
- Hunter G. Lindsay (ORCID: https://orcid.org/0000-0003-0549-353X)
- Chloe C. Kang
- Kimball Demars
Institutions
- Brigham Young University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1562662
- Citations
- 3
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Brigham Young University
- National Institute of Allergy and Infectious Diseases