Diagnosis of Prostate Cancer Recurrence with PSA Levels below 0.2 ng/ml with Intermittent Antiandrogen Therapy

Abstract A case of investigation of a patient with recurrent prostate cancer after Radical Prostatectomy (RP) followed with 70 Gray irradiation (RT) due to numerous positive margins is reported. The Prostate Specific Antigen (PSA) level was fluctuating below 0.2 ng/mL. Comprehensive data on symptoms, Ultrasound (US) measurements, medical treatment, and PSA level fluctuations during intermittent Antiandrogen Therapy (ADT) were analyzed. ADT led to reduction in the size of the cancer by almost half. The PSA level decreased in accordance with the ADT injections. US with Doppler showed an area with increased blood flow. A nano-knife procedure was applied to this suspicious area. Then the Pfizer vaccine was administered, as a result of the final two treatments the PSA level dropped to 0,006 ng/ml. All the symptoms disappeared.