SORBS3-β suppresses lymph node metastasis in cervical cancer by promoting the ubiquitination of β-catenin
SORBS3-β is the major isoform of SORBS3 that inhibits lymphatic metastasis of cervical cancer by degrading β-catenin through UBA1-mediated ubiquitination, blocking Wnt/β-catenin signaling and downstream lymphangiogenesis pathways, thereby inhibiting lymphatic metastasis. Our findings elucidate key molecular mechanisms underlying cervical cancer lymph node metastasis, offering potential therapeutic targets.metastasis.
Authors
- Jinhua Zhou (ORCID: https://orcid.org/0000-0002-1163-002X)
- Huating Sun
- Zizhao Wang
- Fang Wang (ORCID: https://orcid.org/0000-0001-7731-0283)
- Li Wang (ORCID: https://orcid.org/0000-0003-2165-0080)
- Yinghui Zhang (ORCID: https://orcid.org/0000-0002-9108-0813)
- Youguo Chen (ORCID: https://orcid.org/0000-0001-8026-664X)
- Yuhong Zhang (ORCID: https://orcid.org/0000-0003-4230-5868)
Institutions
- Soochow University (CN)
- Jingzhou Maternal and Child Health Hospital (CN)
- Suzhou Municipal Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1186/s12967-025-06409-2
- Citations
- 3
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China