Insufficient CXCL13 secretion in leprosy foamy macrophages attenuates lymphocyte recruitment and antimicrobial protein production
In conclusion, the NLRP12/NF-κB/CXCL13 axis is crucial for the immune response of FMs after mycobacterial infection. These findings contribute to a deeper understanding of the pathological mechanisms of mycobacterial infection.
Authors
- Hong Liu (ORCID: https://orcid.org/0000-0002-5182-4750)
- Peidian Shi (ORCID: https://orcid.org/0000-0002-2081-2634)
- Zihao Mi (ORCID: https://orcid.org/0000-0002-2912-6374)
- Furen Zhang (ORCID: https://orcid.org/0000-0002-3383-1973)
- Honglei Wang (ORCID: https://orcid.org/0000-0001-5535-6651)
- Wenchao Li (ORCID: https://orcid.org/0000-0003-4982-3756)
- Zhenzhen Wang (ORCID: https://orcid.org/0000-0001-5927-2471)
- Tingting Liu (ORCID: https://orcid.org/0000-0002-8168-6117)
- Chuan Wang (ORCID: https://orcid.org/0000-0003-3079-8431)
- Yuan Zhang (ORCID: https://orcid.org/0000-0001-5482-8864)
Institutions
- Shandong Provincial Institute of Dermatology and Venereology (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1541954
- Primary Topic
- Leprosy Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Shandong First Medical University