Mediation Effect of Relaxin in Cerebrospinal Fluid on the Association Between Smoking and Sleep
CSF relaxin levels were significantly elevated in smokers and closely associated with PSQI subdimension scores, particularly with the sleep disturbance subdimension score. Moreover, CSF relaxin mediated the relationship between nicotine dependence and sleep quality. Polymorphisms (RLN3 rs12327666, rs1982632, and rs7249702, RLN3R1 rs35399, and RLN3R2 rs11264422) also played a role in smoking behaviors or sleep quality.
Authors
- Zeping Xu (ORCID: https://orcid.org/0000-0002-5703-4194)
- Kexin Wang (ORCID: https://orcid.org/0009-0005-9008-7756)
- Xiyi Chen (ORCID: https://orcid.org/0000-0001-7855-1177)
- Ke Zheng (ORCID: https://orcid.org/0000-0002-4624-0881)
- Yu-Yu Wu (ORCID: https://orcid.org/0000-0001-5302-547X)
- Jiayi Tang
- Fan Wang (ORCID: https://orcid.org/0000-0002-7048-8166)
- Yimin Kang
- Li Chen (ORCID: https://orcid.org/0000-0001-8978-0864)
- Xingguang Luο (ORCID: https://orcid.org/0000-0003-3585-042X)
- Mingwei Ma (ORCID: https://orcid.org/0000-0002-6942-6128)
- Yanlong Liu (ORCID: https://orcid.org/0000-0001-7427-2533)
- Yu-Hsin Chen
- Weiming Hu (ORCID: https://orcid.org/0000-0001-9237-8825)
Institutions
- Ningbo University (CN)
- Wenzhou Medical University (CN)
- Yale University (US)
- Ningbo Medical Center Lihuili Hospital (CN)
- Jinzhou Kangning Hospital (CN)
- Beijing HuiLongGuan Hospital (CN)
- Wenzhou City People's Hospital (CN)
- Inner Mongolia Medical University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Nature and Science of Sleep
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/nss.s479171
- Primary Topic
- Pregnancy-related medical research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Ningbo