The role of long non-coding RNAs in angiogenesis in ischemic stroke: new perspectives based on advanced techniques in neuroscience

Ischemic stroke is a leading cause of long-term disability and death, making it crucial to understand the underlying cellular and molecular mechanisms. Research into these mechanisms has gained significant attention, with a particular focus on long noncoding RNAs, which are greater than 200 nucleotides in length. Recent studies using RNA sequencing, deep sequencing, and microarrays have identified numerous long non-coding RNAs that are aberrantly expressed in both patients with ischemic stroke and animal models of ischemic injury. In recent years, research on long non-coding RNAs has identified various types that exhibit both vascular protective effects and harmful effects, which are related to the regulation of vascular regeneration in the nervous system. These findings offer new targets for the study of ischemic stroke. The purpose of this review is to summarize the current research progress on the role of long non-coding RNAs in angiogenesis after ischemic stroke and to explore their potential clinical significance and new technologies. With advances in new technologies, such as RNA sequencing and deep sequencing, researchers can gain deeper insights into the functions and mechanisms of long noncoding RNAs. The application of these technologies has not only enhanced the understanding of the role of long non-coding RNAs in stroke but also opened up possibilities for the development of new therapeutic strategies. This review highlights the critical roles of long non-coding RNAs such as MALAT1, XIST, and MEG3 in angiogenesis after ischemic stroke and discusses how they participate in this process through different molecular mechanisms. These findings provide new molecular targets for the treatment of ischemic stroke and pave the way for future research. As new technological advancements emerge, there is hope for a deeper understanding of long non-coding RNAs in ischemic stroke, which could assist in the development of more precise tools for clinical diagnosis and treatment. Although there are still challenges to overcome, the prospects for long non-coding RNA research are encouraging, and they are anticipated to play a crucial role in the study and management of ischemic stroke.