Vaccinium myrtillus L. ameliorates diabetic nephropathy via modulating metabolites and gut microbiota in rats
Our findings suggest that the improvement of gut microbiota and metabolic function were related to the anti-DN potential of VCE, and the underlying mechanism may be related to the inhibition of MAPK/NF-κB signaling pathway.
Authors
- Xinxin Cao (ORCID: https://orcid.org/0000-0001-7884-3073)
- Ruikun He (ORCID: https://orcid.org/0000-0002-2292-8884)
- Fan Yao
- Bin Zhang (ORCID: https://orcid.org/0009-0008-7206-144X)
- Zhen Zhang (ORCID: https://orcid.org/0000-0002-9898-054X)
- Yufang Wang (ORCID: https://orcid.org/0000-0003-1597-3289)
- Chongyang Zhang (ORCID: https://orcid.org/0000-0002-7833-5172)
- Zhengqi Dong (ORCID: https://orcid.org/0000-0001-9968-9992)
- Xiaobo Sun
- Wenxiu Liu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- China National Health Development Research Center (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.3389/fphar.2025.1541947
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China