Expression of innate immunity genes in human hematopoietic stem/progenitor cells – single cell RNA-seq analysis
To our best knowledge, it is the first time that expression of complosome elements was studied in HSPCs at the single cell resolution with the use of single cell sequencing. Thus, our data sheds new light on complosome as a novel regulator of hematopoiesis that involves intracrine activation of the C5a-C5aR-Nlrp3 inflammasome axis.
Authors
- Magda Kucia (ORCID: https://orcid.org/0000-0002-9110-5048)
- Mariusz Z. Ratajczak (ORCID: https://orcid.org/0000-0002-0071-0198)
- Justyna Jarczak (ORCID: https://orcid.org/0000-0002-4357-7681)
- Kamila Bujko (ORCID: https://orcid.org/0000-0002-2205-1154)
- Diana Wierzbicka (ORCID: https://orcid.org/0009-0002-8027-2163)
- Kannathasan Thetchinamoorthy (ORCID: https://orcid.org/0000-0002-4697-7330)
Institutions
- University of Louisville (US)
- Medical University of Warsaw (PL)
- James Graham Brown Foundation (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1515856
- Citations
- 4
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 3.19