External ligand-free nickel-catalyzed atom-economical coupling of isatins with allyl alcohols <i>via</i> a redox-relay strategy
Herein, we present a redox-relay strategy that enables the nickel-catalyzed, atom-economical coupling of isatins and allyl alcohols. This reaction is notable for its lack of requirement for additional ligands or reducing agents, and minimal catalyst usage (only 1%), thus meeting the principles of green chemistry. Mechanistic studies have shown that allyl alcohols act as both reductants and precursors for α,β-unsaturated ketones in the reaction.
Authors
- Jiaxue Wang (ORCID: https://orcid.org/0000-0002-9789-034X)
- Yuxin He (ORCID: https://orcid.org/0000-0002-8760-8988)
- Qun Peng
- Rong‐Hua Wang
- Hui Zhao (ORCID: https://orcid.org/0000-0003-3220-5484)
- Miao Li (ORCID: https://orcid.org/0000-0003-3720-5336)
- Bo Li (ORCID: https://orcid.org/0000-0003-3778-6329)
- Bin Liu (ORCID: https://orcid.org/0000-0002-3977-8800)
- Lei Tang (ORCID: https://orcid.org/0000-0003-1273-9040)
- Jiayu Huang (ORCID: https://orcid.org/0009-0005-3144-3108)
- Ming-Bai Gou
- Zhen-Qi Luo
- Qing He
Institutions
- Guiyang Medical University (CN)
- Zhejiang Industry Polytechnic College (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01200g
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00