Impact of repetitive transcranial magnetic stimulation on clinical and cognitive outcomes, and brain-derived neurotrophic factor levels in treatment-resistant depression
rTMS reduced depressive symptoms in TRD patients, with modest cognitive benefits. Baseline BDNF did not predict outcomes, though the lack of significant change suggests complex neuroplastic responses. Future studies should include larger samples and refined biomarker assessments.
Authors
- Federica Pinna (ORCID: https://orcid.org/0000-0002-3108-9509)
- Enrico Ginelli
- Lucia Sanna
- Bernardo Carpiniello (ORCID: https://orcid.org/0000-0002-5385-7871)
- Clement C. Zai (ORCID: https://orcid.org/0000-0003-0496-7262)
- María Scherma (ORCID: https://orcid.org/0000-0001-8652-9594)
- Mirko Manchia (ORCID: https://orcid.org/0000-0003-4175-6413)
- Ulker Isayeva (ORCID: https://orcid.org/0000-0003-3927-4810)
- Pasquale Paribello (ORCID: https://orcid.org/0000-0001-9953-6929)
- Giorgio Corona
- Maria Novella Iaselli
- Paola Fadda (ORCID: https://orcid.org/0000-0002-0642-6710)
- Roberto Collu (ORCID: https://orcid.org/0000-0001-8887-1852)
- Daniela Manca
Institutions
- Dalhousie University (CA)
- Centre for Addiction and Mental Health (CA)
- University of Cagliari (IT)
- University of Toronto (CA)
- National Research Council (IT)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-04-08
- DOI
- https://doi.org/10.3389/fpsyt.2025.1584673
- Citations
- 2
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.68