Effects of the ketogenic diet on dentate gyrus and CA3 KCC2 expression in male rats with electrical amygdala kindling-induced seizures
KD reduces ADD in generalized seizures. In addition, KD has a putative neuroprotective effect by preventing the kindling-induced reduction of KCC2 expression in the molecular, granule, and hilar dentate gyrus layers and pyramidal and lucidum CA3 strata. Increased KCC2 expression levels are related to a shorter duration of generalized seizures.
Authors
- Joyce Graciela Martínez-Galindo
- Pilar Durán (ORCID: https://orcid.org/0000-0002-3252-041X)
- Miguel Tapia‐Rodríguez (ORCID: https://orcid.org/0000-0002-2248-6596)
- Tarsila Elizabeth Juárez-Zepeda
- América Vanoye–Carlo (ORCID: https://orcid.org/0000-0002-4539-4758)
- Veronica Ramírez-R. (ORCID: https://orcid.org/0000-0002-4776-7351)
- Carmen Rubio (ORCID: https://orcid.org/0000-0002-4775-5043)
- Leonor Hernández‐López
- Leticia Granados-Rojas
- Karina Jerónimo-Cruz
- Emmanuel Leonardo Bahena-Alvarez
Institutions
- Instituto Nacional de Pediatria (MX)
- Instituto Nacional de Neurología y Neurocirugía (MX)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-04-08
- DOI
- https://doi.org/10.3389/fnins.2025.1489407
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00