Genetic determinants of HIV-1 subtype C Nef-mediated SERINC3 down-regulation
Although SERINC3 down-regulation did not associate significantly with markers of HIV disease progression, our results nevertheless suggest that SERINC3 down-regulation contributes significantly to overall Nef function and fitness. The identification of Nef amino acids associated with differential SERINC3 down-regulation ability may be useful for rational design of therapeutics and vaccines targeting the Nef region.
Authors
- Mark A. Brockman (ORCID: https://orcid.org/0000-0001-6432-1426)
- Nasreen Ismail (ORCID: https://orcid.org/0000-0001-7026-3605)
- Tarylee Reddy (ORCID: https://orcid.org/0000-0002-9521-2692)
- Thumbi Ndung’u (ORCID: https://orcid.org/0000-0003-2962-3992)
- Jaclyn K. Mann (ORCID: https://orcid.org/0000-0002-2398-1273)
- Zabrina L. Brumme (ORCID: https://orcid.org/0000-0002-8157-1037)
- Nikeisha Samlall
Institutions
- South African Medical Research Council (ZA)
- Simon Fraser University (CA)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- Ragon Institute of MGH, MIT and Harvard (US)
- Africa Health Research Institute (ZA)
- AIDS Vancouver (CA)
- University College London (GB)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1186/s12985-025-02705-x
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bill and Melinda Gates Foundation
- Poliomyelitis Research Foundation