MiR-204-5p promoted maternally expressed gene 3 (MEG3) through SP1-mediated DNMT1 pathway in trophoblast cells in recurrent miscarriage
miR-204-5p promoted MEG3 expression in trophoblast cells via SP1-mediated DNMT1 inhibition, leading to reduced cell migration, proliferation and invasion, as well as increased apoptosis. This study reveals a novel regulatory axis in trophoblast cells, providing insights into potential regulatory mechanisms in RM.
Authors
- Xinran Xu (ORCID: https://orcid.org/0000-0001-6435-8181)
- Yiping Gao (ORCID: https://orcid.org/0000-0003-4509-3012)
- Yue Wang (ORCID: https://orcid.org/0000-0003-3263-6794)
- Shasha Liu (ORCID: https://orcid.org/0000-0003-1937-1314)
- Lan Cheng (ORCID: https://orcid.org/0000-0003-2034-5586)
- Yuling Guo (ORCID: https://orcid.org/0009-0008-1919-2862)
Institutions
- Tianjin Central Hospital of Gynecology Obstetrics (CN)
Publication Details
- Journal
- Advances in Clinical and Experimental Medicine
- Published
- 2025-04-08
- DOI
- https://doi.org/10.17219/acem/195925
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00