High interleukin-35 expression is associated with the severity of rheumatic mitral stenosis
We show for the first time an increase of IL-35 level in the blood and MV tissues of RMS patients, which is strongly correlated with the severity of RMS. These results suggest that IL-35 plays an important regulatory role in the progression of RMS.
Authors
- Yong Zhan (ORCID: https://orcid.org/0000-0003-4144-9915)
- Bin Liu (ORCID: https://orcid.org/0000-0003-0407-6486)
- Ping Wang (ORCID: https://orcid.org/0000-0003-2956-8700)
- Peng Zhang (ORCID: https://orcid.org/0000-0002-1806-4200)
- Peng Li (ORCID: https://orcid.org/0000-0002-9026-9999)
- Xuezhen Gao
- Li Zhao (ORCID: https://orcid.org/0009-0003-8269-835X)
- Yaxiong Li (ORCID: https://orcid.org/0000-0003-2661-5524)
- Zhibin Cai
Institutions
- Tufts University (US)
- Tufts Medical Center (US)
- Kunming Medical University (CN)
- Fuwai Yunnan Cardiovascular Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1537497
- Primary Topic
- Streptococcal Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Sciences
- Kunming Medical University
- Chinese Academy of Medical Sciences
- Applied Basic Research Foundation of Yunnan Province
- Instytut Biologii Medycznej Polskiej Akademii Nauk