Protective effects of 4-HBd on blood–brain barrier integrity in MCAO/R model rats based on brain pharmacokinetic characteristics
These findings indicate that 4-HBd exerts a pronounced brain-targeting effect and preserves BBB integrity via the RNS/ROS-MMP-TJ signaling pathway, highlighting its potential as a therapeutic agent for IS.
Authors
- Jianjun Cheng (ORCID: https://orcid.org/0000-0003-2561-9291)
- Fangyan He
- Qingting Meng
- Xue-Lan Song
- Qian Yang (ORCID: https://orcid.org/0000-0003-3243-3153)
- Qing Lin (ORCID: https://orcid.org/0000-0002-8890-800X)
- Yan Wang (ORCID: https://orcid.org/0009-0002-3005-8134)
- Ming Chen (ORCID: https://orcid.org/0000-0002-6114-1750)
- Feng Jin (ORCID: https://orcid.org/0000-0002-3035-2723)
- Xiaonan Zhou
- Dan Luo (ORCID: https://orcid.org/0000-0003-2117-0570)
- Dongxiong Hu
Institutions
- Yunnan University (CN)
- Yunnan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.3389/fphar.2025.1528839
- Citations
- 1
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.84