Palladium-catalyzed Narasaka–Heck carbonylation for the construction of functionalized ynones
A palladium-catalyzed tandem carbonylation reaction has been developed for the construction of ynones. This reaction is characterized by readily available starting materials, broad functional group compatibility, and the use of CO as the carbonyl source. Unlike conventional carbonylation methods for synthesizing ynones, this strategy enables the efficient preparation of dialkyl chain-substituted ynones under atmospheric CO pressure. Further gram-scale experiments and derivative synthesis demonstrate the significant synthetic utility of this approach.
Authors
- Xi‐Cun Wang (ORCID: https://orcid.org/0000-0003-3770-9817)
- Shun‐Xi Li
- Yi‐Feng Qiu (ORCID: https://orcid.org/0000-0002-2747-9598)
- Dong‐Ping Chen (ORCID: https://orcid.org/0009-0004-5314-7740)
- Fei Yang (ORCID: https://orcid.org/0000-0001-7390-7111)
- Ming Li (ORCID: https://orcid.org/0000-0002-2207-0873)
- Xueliang Zhang (ORCID: https://orcid.org/0000-0001-6188-0257)
- Zheng‐Jun Quan (ORCID: https://orcid.org/0000-0002-4393-3594)
- Shan-Mei Xu
- Yong‐Min Liang (ORCID: https://orcid.org/0000-0001-8280-8211)
Institutions
- Northwest Normal University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc00859j
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Northwest Normal University
- National Natural Science Foundation of China