Vascular Cell Adhesion Molecule-1 in Diabetic Retinopathy and Retinal Vein Occlusion: Association and Mechanistic Insights

血管细胞粘附分子1 (VCAM-1)属于免疫球蛋白家族的细胞粘附分子(CAM)，主要通过调节白细胞与内皮细胞的粘附在许多急性或慢性炎症疾病中起着关键作用。近些年随着对眼部疾病的研究，发现VCAM-1与糖尿病视网膜病变、视网膜静脉阻塞等相关疾病具有相关性，但其确切的发病机制有待进一步研究，本文对VCAM-1与糖尿病视网膜病变及视网膜静脉阻塞的相关性进行探讨，为诊断及治疗这些疾病提供新的思路和方法。Vascular cell adhesion molecule-1 (VCAM-1), a member of the immunoglobulin superfamily of cell adhesion molecules (CAMs), plays a pivotal role in acute and chronic inflammatory diseases by mediating leukocyte-endothelial adhesion. Recent advances in ophthalmic research have identified potential correlations between VCAM-1 and diabetic retinopathy (DR) as well as retinal vein occlusion (RVO). However, the exact pathogenic mechanisms remain incompletely elucidated. This article explores the association of VCAM-1 with DR and RVO, aiming to provide novel insights for the diagnosis and therapeutic intervention of these conditions.