Bacteria-responsive cytoderm drug delivery systems
Signs of bacterial activities have been reported in a variety of disease models. Here, we extracted plant cytoderm ghosts (PCGs) from plant cells, acting as bacteria-responsive drug delivery systems (DDSs) that release drugs specifically in response to the presence or activity of bacteria. Cellulose, which is one of the main components of PCGs, can be degraded in the presence of specialized bacteria that secrete enzymes to convert the cellulose into simpler sugars, thus breaking down the structure of PCGs to release the loaded drugs. In our study, PCGs loaded with ciprofloxacin (PCG@CIP) could effectively inhibit the proliferation and retention of bacteria at the infection site, and improve the local wound microenvironment to accelerate wound repair. In addition, the PCG platform with anticancer drugs could effectively regulate the progression of tumor growth. Therefore, we report a new drug delivery system that responds to the microbiota based on plant cytoderm, providing a new option for drug responsive delivery.
Authors
- Wenju Chang (ORCID: https://orcid.org/0000-0003-1182-4083)
- Jinyu Bai
- Bingbing Wu (ORCID: https://orcid.org/0000-0001-9269-4414)
- Tongguo Shi (ORCID: https://orcid.org/0000-0002-5382-2775)
- Yue Yu (ORCID: https://orcid.org/0000-0002-2617-459X)
- Chao Wang (ORCID: https://orcid.org/0000-0002-8054-3472)
- Fang Xu (ORCID: https://orcid.org/0000-0002-7357-5177)
- Chenmeng Zhou (ORCID: https://orcid.org/0009-0004-2979-4091)
- Bo Tian (ORCID: https://orcid.org/0000-0001-5480-888X)
- Dongxiao Li (ORCID: https://orcid.org/0009-0007-7909-1898)
- Yue Zhang (ORCID: https://orcid.org/0000-0002-7786-0231)
Institutions
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Biomaterials Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5bm00026b
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions
- Higher Education Discipline Innovation Project