Genomic and molecular characterization of a ceftazidime-avibactam resistant Klebsiella pneumoniae strain isolated from a Chinese tertiary hospital

This study reports the first identification of a ceftazidime-avibactam resistant K. pneumoniae ST685 strain carrying bla_NDM-5 in Ningbo, Zhejiang Province, China. The findings underscore the urgent need for implementing comprehensive antimicrobial resistance surveillance programs and strengthening infection control measures to mitigate the dissemination of IncX3-type plasmids harboring bla_NDM-5 in healthcare settings. Furthermore, our results emphasize the critical importance of establishing rapid enzymatic detection platforms in clinical microbiology laboratories to facilitate timely and precise therapeutic decision-making, thereby optimizing antimicrobial stewardship and improving patient outcomes.