Efficient One‐Step Synthesis of Lactide with High Yield and Selectivity Using Brønsted Acid Catalysis
In this work, a one-step method synthesis of lactide is reported instead of the traditional two-step method. The selection of a suitable acid catalyst polyphosphoric acid and optimization of reaction conditions result in a yield of 97%. Moreover, this new one-step strategy eliminates the need for metal catalysts and does not require high-temperature conditions, thereby avoiding the issue of racemization. The simple one-step strategy offers a combination of efficiency, sustainability, and product quality improvements, making it a modern, practical approach to lactide synthesis.
Authors
- Zongxia Guo (ORCID: https://orcid.org/0000-0003-2607-4019)
- Yukang Liu (ORCID: https://orcid.org/0000-0003-4682-3937)
- Yufei Zhang (ORCID: https://orcid.org/0000-0002-5890-3056)
- Hui Liu (ORCID: https://orcid.org/0000-0002-7648-0915)
- Xiaotao Wang
- Wenqi Qiu
- Yuxia Guo (ORCID: https://orcid.org/0000-0003-0014-6862)
- Canbin Ouyang (ORCID: https://orcid.org/0000-0001-9295-1273)
- Yingjie Zhao (ORCID: https://orcid.org/0000-0003-3433-5039)
Institutions
- Qingdao University of Science and Technology (CN)
- Institute of Plant Protection (CN)
- Chinese Academy of Agricultural Sciences (CN)
- State Key Laboratory of Biology of Plant Diseases and Insect Pests
Publication Details
- Journal
- ChemSusChem
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1002/cssc.202500100
- Citations
- 1
- Primary Topic
- biodegradable polymer synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.60
Funders
- National Natural Science Foundation of China