Immunomarker profiling in human chronic wound swabs reveals IL-1 beta/IL-1RA and CXCL8/CXCL10 ratios as potential biomarkers for wound healing, infection status and regenerative stage
Immunomarker profiling via wound swabbing offers valuable insights into the wound healing process. Elevated levels of pro-inflammatory cytokines and MMPs are associated with chronic inflammation and impaired healing. The IL- 1β/IL- 1RA and CXCL8/CXCL10 ratios emerge as promising biomarkers to distinguish between infection and inflammation, with potential in targeted wound care. Further studies are needed to validate these findings and implement them in clinical practice.
Authors
- Matthias Augustin (ORCID: https://orcid.org/0000-0002-4026-8728)
- Joachim Dissemond (ORCID: https://orcid.org/0000-0003-3893-328X)
- Julian‐Dario Rembe (ORCID: https://orcid.org/0000-0002-5176-6941)
- Waseem Garabet (ORCID: https://orcid.org/0009-0005-9271-8697)
- Hubert Schelzig
- Wiebke Ibing
- Ewa K. Stuermer
Institutions
- Universität Hamburg (DE)
- Düsseldorf University Hospital (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Essen University Hospital (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1186/s12967-025-06417-2
- Citations
- 20
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 20.52
Funders
- Medizinische Fakultät, Heinrich-Heine-Universität Düsseldorf