Research Progress on the Role of Neutrophil Extracellular Traps in Pulmonary Hypertension

肺动脉高压是一种以肺血管阻力和肺动脉压力升高为特征的临床和病理生理综合征，预后较差，全球疾病负担重。中性粒细胞胞外诱捕网，是一种由活化的中性粒细胞释放至胞外的网状结构，在慢性炎症、血管重塑及血栓形成中发挥重要作用，或可为肺动脉高压的早期识别及治疗提供新思路。因而，本文就中性粒细胞胞外诱捕网在肺动脉高压发生发展中的作用及潜在治疗方案进行阐述。Pulmonary hypertension (PH) is a clinical and pathophysiological syndrome characterized by increased pulmonary vascular resistance and elevated pulmonary arterial pressure, with poor prognosis and severe global disease burden. Neutrophil extracellular traps (NETs), a network released by activated neutrophils, play a critical role in chronic inflammation, vascular remodeling, and thrombosis, providing novel insights for early identification and therapeutic strategies in PH. Hence, this article reviews the role of NETs in the pathogenesis and progression of PH, as well as explores potential treatment approaches targeting NETs.