Research Progress of Platelet-Rich Plasma in the Treatment of Discogenic Low Back Pain

本综述整理了富血小板血浆(Platelet-Rich Plasma, PRP)在椎间盘源性腰痛(Discogenic Low Back Pain, DLBP)治疗中的研究进展。通过查阅近年来相关文献，分析了PRP的作用机制、制备及活化方式，并探讨了其在动物实验和人体实验中的效果。PRP通过血小板分泌的生物活性因子对DLBP具有潜在治疗作用，可通过传统或商用方法制备并活化。动物实验显示，PRP对椎间盘退变(Intervertebral Disc Degeneration, IDD)具有显著疗效，改善MRI信号；人体实验则表明PRP可改善疼痛和功能评分，尽管部分研究结果存在差异。现有研究表明PRP安全性较高，但关于其分类、制备及活化方法存在异质性。影像学评估PRP疗效的研究较少，未来需开展更大规模的临床试验，纳入更多客观指标评估其疗效，并通过系统性综述和学术会议制定相关指南，指导PRP的临床应用。This review provides an overview of the research progress on Platelet-Rich Plasma (PRP) in the treatment of Discogenic Low Back Pain (DLBP). By examining recent literature, we explore the mechanisms of action, preparation, and activation of PRP, as well as its effects in both animal and human studies. PRP shows potential therapeutic benefits for DLBP through bioactive factors secreted by platelets, and it can be prepared and activated using either traditional or commercial methods. Animal studies have demonstrated significant improvements in Intervertebral Disc Degeneration (IDD), including enhanced MRI signals. In human studies, PRP has been shown to improve pain and functional scores, though some studies report varying results. While existing research confirms the safety of PRP, there is considerable variation in its classification, preparation, and activation methods. Additionally, there is a lack of studies utilizing imaging to assess PRP’s efficacy. Future clinical trials should be larger in scale, incorporating more objective measures, and systematic reviews and academic conferences are needed to establish guidelines for the clinical use of PRP.